Arnold Beckman

Arnold Orville Beckman (April 10, 1900 – May 18, 2004) was an American chemist, inventor, investor, and philanthropist. While a professor at California Institute of Technology, he founded Beckman Instruments based on his 1934 invention of the pH meter, a device for measuring acidity (and alkalinity), later considered to have "revolutionized the study of chemistry and biology". He also developed the DU spectrophotometer, "probably the most important instrument ever developed towards the advancement of bioscience". Beckman funded the Shockley Semiconductor Laboratory, the first silicon transistor company in California, thus giving rise to Silicon Valley. In 1965, he retired as president of Beckman Instruments, instead becoming the chairman of its board of directors. On November 23, 1981, he agreed to sell the company, which was then merged with SmithKline to form SmithKline Beckman. After retirement, he and his wife Mabel (1900–1989) were numbered among the top philanthropists in the United States.

Beckman was born in Cullom, Illinois, a village of about 500 people in a farming community. He was the youngest son of George Beckman, a blacksmith, and his second wife Elizabeth Ellen Jewkes. He was curious about the world from an early age. When he was nine, Beckman found an 1868 chemistry textbook, Joel Dorman Steele's Fourteen Weeks in Chemistry, and began trying out the experiments. His father encouraged his scientific interests by letting him convert a toolshed into a laboratory.

Beckman's mother, Elizabeth, died of diabetes in 1912. Beckman's father sold his blacksmith shop, and became a travelling salesman for blacksmithing tools and materials. A housekeeper, Hattie Lange, was engaged to look after the Beckman children. Arnold Beckman earned money as a "practice pianist" with a local band, and as an "official cream tester" running a centrifuge for a local store.

In 1914, the Beckman family moved to Normal, located just north of Bloomington, Illinois, so that the young Beckmans could attend University High School in Normal, a "laboratory school" associated with Illinois State University. In 1915 they moved to Bloomington itself, but continued to attend University High, where Arnold Beckman obtained permission to take university level classes from professor of chemistry Howard W. Adams. While still in high school, Arnold started his own business, "Bloomington Research Laboratories", doing analytic chemistry for the local gas company. He also performed at night as a movie-house pianist, and played with local dance bands. He graduated valedictorian of his class, with an average of 89.41 over four years, the highest attained.

Beckman was allowed to leave school a few months early to contribute to the First World War effort in early 1918 by working as a chemist. At Keystone Steel and Iron he took samples of molten iron and tested them to see if the chemical composition of carbon, sulfur, manganese and phosphorus was suitable for pouring steel.

When Beckman turned 18 in August 1918, he enlisted in the United States Marines. After three months at marine boot camp on Parris Island, South Carolina, he was sent to the Brooklyn Navy Yard, for transit to the war in Europe. Because of a train delay, another unit embarked in place of Beckman's unit. Then, counted into groups in the barracks, Beckman missed being sent to Russia by one space in line. Instead, Arnold spent Thanksgiving at the local YMCA, where he met 17-year-old Mabel Stone Meinzer, who was helping to serve the meal. Mabel would become his wife. A few days later, the armistice was signed, ending the war.

Beckman attended the University of Illinois Urbana–Champaign beginning in the fall of 1918. During his freshman year, he worked with Carl Shipp Marvel on the synthesis of organic mercury compounds, but both men became ill from exposure to toxic mercury. As a result, Beckman changed his major from organic chemistry to physical chemistry, where he worked with Worth Rodebush, T. A. White, and Gerhard Dietrichson. He earned his bachelor's degree in chemical engineering in 1922 and his master's degree in physical chemistry in 1923. For his master's degree he studied the thermodynamics of aqueous ammonia solutions, a subject introduced to him by T. A. White.

Soon after arriving at the University of Illinois, Beckman joined the Delta Upsilon fraternity. He was initiated into Zeta chapter of Alpha Chi Sigma, the chemistry fraternity, in 1921 and the Gamma Alpha Graduate Scientific Fraternity in December 1922.

Beckman decided to go to California Institute of Technology (Caltech) for his doctorate. He stayed there for a year, before returning to New York to be near his fiancée, Mabel, who was working as a secretary for the Equitable Life Assurance Society. He found a job with Western Electric's engineering department, the precursor to the Bell Telephone Laboratories. Working with Walter A. Shewhart, Beckman developed quality control programs for the manufacture of vacuum tubes and learned about circuit design. It was here that Beckman discovered his interest in electronics.

The couple married June 10, 1925and moved back to California in 1926, where Beckman resumed his studies at Caltech. He became interested in ultraviolet photolysis and worked with his doctoral advisor, Roscoe G. Dickinson, on an instrument to find the energy of ultraviolet light. It worked by shining the ultraviolet light onto a thermocouple, converting the incident heat into electricity, which drove a galvanometer. After receiving a Ph.D. in photochemistry in 1928 for this application of quantum theory to chemical reactions, Beckman was asked to stay on at Caltech as an instructor and then as a professor. Linus Pauling, another of Roscoe G. Dickinson's graduate students, was also asked to stay on at Caltech.

During his time at Caltech, Beckman was active in teaching at both the introductory and advanced graduate levels. Beckman shared his expertise in glass-blowing by teaching classes in the machine shop. He also taught classes in the design and use of research instruments. Beckman dealt first-hand with the chemists' need for good instrumentation as manager of the chemistry department's instrument shop. Beckman's interest in electronics made him very popular within the chemistry department at Caltech, as he was very skilled in building measuring instruments.

Over the time that he was at Caltech, the focus of the department increasingly moved towards pure science and away from chemical engineering and applied chemistry. Arthur Amos Noyes, head of the chemistry division, encouraged both Beckman and chemical engineer William Lacey to be in contact with real-world engineers and chemists, and Robert Andrews Millikan, Caltech's president, referred technical questions to Beckman from government and businesses. With their blessing, Beckman began accepting outside work as a scientific and technical consultant. He also acted as a scientific expert in legal trials.

In 1934, Millikan referred I. H. Lyons from the National Postal Meter Company to Arnold Beckman. Lyons wanted a non-clogging ink so that postage could be printed by machines, instead of having clerks lick stamps. Beckman's solution was to make ink with butyric acid, a malodorous substance. Because of this ingredient, no manufacturer wanted to manufacture it. Beckman decided to make it himself. He started the National Inking Appliance Company, obtaining space in a garage owned by instrument maker Fred Henson and hiring two Caltech students, Robert Barton and Henry Fracker. Beckman developed and took out a couple of patents for re-inking typewriter ribbons, but marketing them was not successful. This was Beckman's first experience at running a company and marketing a product, and while this first product failed, Beckman repurposed the company for another product.

Sunkist Growers was having problems with its own manufacturing process. Lemons that were not saleable as produce were made into pectin or citric acid, with sulfur dioxide used as a preservative. Sunkist needed to know the acidity of the product at any given time, and the colorimetric methods then in use, such as readings from litmus paper, did not work well because sulfur dioxide interfered with them. Chemist Glen Joseph at Sunkist was attempting to measure the hydrogen-ion concentration in lemon juice electrochemically, but sulfur dioxide damaged hydrogen electrodes, and non-reactive glass electrodes produced weak signals and were fragile.

Joseph approached Beckman, who proposed that instead of trying to increase the sensitivity of his measurements, he amplify his results. Beckman, familiar with glassblowing, electricity, and chemistry, suggested a design for a vacuum-tube amplifier and ended up building a working apparatus for Joseph. The glass electrode used to measure pH was placed in a grid circuit in the vacuum tube, producing an amplified signal which could then be read by an electronic meter. The prototype was so useful that Joseph requested a second unit.

Beckman saw an opportunity, and rethinking the project, decided to create a complete chemical instrument which could be easily transported and used by nonspecialists. By October 1934, he had registered patent application US Patent No. 2,058,761 for his "acidimeter", later renamed the pH meter. The Arthur H. Thomas Company, a nationally known scientific instrument dealer based in Philadelphia, was willing to try selling it. Although it was priced expensively at $195, roughly the starting monthly wage for a chemistry professor at that time, it was significantly cheaper than the estimated cost of building a comparable instrument from individual components, about $500. The original pH meter weighed in at nearly 7 kg, but was a substantial improvement over a benchful of delicate equipment. The earliest meter had a design glitch, in that the pH readings changed with the depth of immersion of the electrodes, but Beckman fixed the problem by sealing the glass bulb of the electrode.

On April 8, 1935, Beckman renamed his company National Technical Laboratories, formally acknowledging his new focus on the making of scientific instruments. The company rented larger quarters at 3330 Colorado Street, and began manufacturing pH meters. The pH meter is an important device for measuring the pH of a solution, and by 11 May 1939, sales were successful enough that Beckman left Caltech to become the full-time president of National Technical Laboratories. By 1940, Beckman was able to take out a loan to build his own 12,000 square foot factory in South Pasadena.

In 1940, the equipment needed to measure light energy in the visible spectrum could cost a laboratory as much as $3,000, a huge amount at that time. There was also growing interest in examining ultraviolet spectra beyond that range. Just as Beckman had created a single easy-to-use instrument for measuring pH, he made it a goal to create an easy-to-use instrument for spectrophotometry. Beckman's research team, led by Howard Cary, developed several models.

The new spectrophotometers used a prism to separate light into its absorption spectrum and a phototube to electrically measure the light energy across the spectrum. They allowed the user to plot the light absorption spectrum of a substance, giving a standardized "fingerprint", characteristic of a compound. With Beckman's model D, later known as the DU spectrophotometer, National Technical Laboratories successfully provided the first easy-to-use single instrument containing both the optical and electronic components needed for ultraviolet-absorption spectrophotometry. The user could insert a sample, dial up the desired wavelength of light, and read the amount of absorption of that frequency from a simple meter. It produced accurate absorption spectra in both the ultraviolet and the visible regions of the spectrum with relative ease and repeatable accuracy. The National Bureau of Standards ran tests to certify that the DU's results were accurate and repeatable and recommended its use.

Beckman's DU spectrophotometer has been referred to as the "model T" of scientific instruments: "This device forever simplified and streamlined chemical analysis, by allowing researchers to perform a 99.9% accurate quantitative measurement of a substance within minutes, as opposed to the weeks required previously for results of only 25% accuracy." Theodore L. Brown notes that it "revolutionized the measurement of light signals from samples". Nobel laureate Bruce Merrifield is quoted as calling the DU spectrophotometer "probably the most important instrument ever developed towards the advancement of bioscience."

Development of the spectrophotometer also had direct relevance to the war effort. For example, the role of vitamins in health was being studied, and scientists wanted to identify Vitamin A-rich foods to keep soldiers healthy. Previous methods involved feeding rats for several weeks, then performing a biopsy to estimate Vitamin A levels. The DU spectrophotometer yielded better results in a matter of minutes. The DU spectrophotometer was also an important tool for scientists studying and producing the new wonder drug penicillin. By the end of the war, American pharmaceutical companies were producing 650 billion units of penicillin each month. Much of the work done in this area during World War II was kept secret until after the war.

Beckman and his company were involved in a number of secret projects. There was a critical shortage of rubber, which was used in jeep and airplane tires and in tanks. Natural sources from the Far East were unavailable because of the war, and scientists sought a reliable synthetic substitute. Beckman was approached by the Office of Rubber Reserve about developing an infrared spectrophotometer to aid in the study of chemicals such as toluene and butadiene. The Office of Rubber Reserve met secretly in Detroit with Robert Brattain of the Shell Development Company, Arnold O. Beckman, and R. Bowling Barnes of American Cyanamid. Beckman was asked to secretly produce a hundred infrared spectrophotometers to be used by authorized government scientists, based on a design for a single-beam spectrophotometer which had already been developed by Robert Brattain for Shell. The result was the Beckman IR-1 spectrophotometer.

At the same time that Beckman was approached about infrared spectrometry, he was contacted by Paul Rosenberg. Rosenberg worked at MIT's Radiation Laboratory. The lab was part of a secret network of research institutions in both the United States and Britain that were working to develop radar, "radio detecting and ranging". The project was interested in Beckman because of the high quality of the tuning knobs or "potentiometers" which were used on his pH meters. Beckman had trademarked the design of the pH meter knobs, under the name "helipot" for "helical potentiometer". Rosenberg had found that the helipot was more precise, by a factor of ten, than other knobs. Nonetheless, for use in continuously moving airplanes, ships, or submarines, which might be under attack, a redesign would be needed to ensure that the knobs could withstand shocks and vibrations.

Beckman was not allowed to tell his staff the reason behind the redesign, and they were not particularly interested in the problem; he eventually came up with a solution himself. Instead of using a wire wrapped around a coil, with pressure from a small spring to create a single contact point, he redesigned the knob to have a continuous groove, in which the contact point was contained. The contact point could then move smoothly and continuously, and could not be jarred out of contact. Beckman's model A Helipot was in tremendous demand by the military. Within the first year of its production, its sales became 40% of the company's income. Beckman spun off a separate company, the Helipot Corporation, to take on the electronics component manufactory.

Linus Pauling at Caltech was also doing secret work for the military. The National Defense Research Committee called a meeting on October 3, 1940, wanting an instrument that could reliably measure oxygen content in a mixture of gases, so that they could measure oxygen conditions in submarines and airplanes. Pauling designed the Pauling oxygen meter for them. Originally approached to supply housing boxes for the meter by Holmes Sturdivant, Pauling's assistant, Beckman was soon asked to produce the entire instrument.

While the board of National Technical Laboratories was unwilling to support the secret project, whose details they could not be told, they agreed that Beckman was free to follow up on it independently. Beckman set up a second spinoff company, Arnold O. Beckman, Inc., for their manufacture. Creating the oxygen meter was a technical challenge, involving the creation of tiny, highly precise glass dumbbells. Beckman created a tiny glass-blowing machine which would generate a precisely measured puff of air to create the glass balls.

After the war, Beckman developed oxygen analyzers for another market. They were used to monitor conditions in incubators for premature babies. Doctors at Johns Hopkins University used them to determine recommendations for healthy oxygen levels for incubators.